Cancer

The protein That Transforms Normal Cells Into Cancer Stem Cells Provides a Target against Cancer of the Colon

It is because of the hangover, all vertebrate mammals may consume food using different techniques such as biting, chewing, and the management of the food. But, did you know the chemicals that are behind the creation of this part of the mouth?

We have not developed the upper and lower jaw, and the teeth buds, the palatal shelves, including some parts of the brain and the bones, if he had not been SATB2.

What is SATB2?

It can be found in the expression of the epithelial cells of the colon and rectum, and also in the neurons of the brain. He plays an active role in the remodeling of chromatin and the regulation of gene transcription. Its ability to bind At-rich DNA sequences is known as a matrix attachment region or (MAR). And because of MAR, it may encode for proteins in the body.

While a mutation in SATB2 is one of the main causes of several diseases, such as osteoporosis, neurological development disorders and speech difficulties, it exposes us to the colorectal cancer too.

Cancer of the colon, which is a global threat to put the lives of patients at stake in the world. Be a metastasis, it is resistant to various anti-cancer drugs and therapies, including chemotherapy, radiation treatment and others. As a result, patients may experience relapse risks once their cells in the tumor to resurface to disturb them again, and little by little the reader on the edge of death.

This new discovery has been highlighted by researchers from the LSU Health New Orleans School of Medicine and Stanley S. Scott Cancer Center. They reported in their online publication in the Research on the Nature of the Scientific Reports. According to their findings, SATB2 is a novel protein, who lives near colon, and becomes malignant.

Since it has metastatic characteristics, it can grow more quickly and spread, and also mimic other stem cells in the body to turn as cancer stem cells.

Develop A View On The Finding

SATB2 is a protein with a built-in function of the capacity of the signaling pathway. Using this switch, it instructs a certain cell in cancer cells to activate, or get disabled. With an activation of certain signals, the cancer cells may transform into cancer stem cells, and seem to perform as indicated by the signal.

Mr. Shrivastava compared to healthy colorectal cells with cells of colorectal cancer, and they found that the good health of the epithelial cells of the colon tissue do not contain activated SATB2 protein, then it is highly activated in colorectal cancer cells.

In order to measure the performance of SATB2, the research team has developed additional copies of the same proteins in normal cells. It has been revealed that these cells had evolved to differentiate and proliferate like the cancer stem cell with a growth rate.

And once the SATB2 expressions are turned off, they do not mimic the characteristics of cancer stem cells, and the growth of colon cells is also suppressed. At the same time, it promotes the prevention of cancer cells to transform into cancer stem cells.

Mr. Shrivastava believes that it is possible to reach a new drug or treatment, and better diagnostic process on the basis of the conclusions of SATB2 as the highest expression of the capacity in colorectal cancer tissue or cells. In addition to this, it could be used as a new marker to identify the severity of colon cancer in patients.

Now, we can be optimistic about the discovery of an agent that can prevent SATB2 affecting the stem cells in the colon tissue to cause of colorectal cancers, and other forms of cancer.

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